23 replies to this topic

[Slidell]

http://bloodjournal....010-09-309591v1
Evidence for the cure of HIV infection by CCR532/32 stem cell transplantation
Kristina Allers^1,*, Gero Hütter², Jörg Hofmann³, Christoph Loddenkemper⁴, Kathrin Rieger², Eckhard Thiel² and Thomas Schneider^{1 1} Department of Gastroenterology, Infectious Diseases, and Rheumatology, Medical Clinic I, Campus Benjamin Franklin, Charite - University Medicine Berlin, Germany; ² Department of Hematology, Oncology, and Transfusion Medicine, Medical Clinic III, Campus Benjamin Franklin, Charite - University Medicine Berlin, Germany; ³ Institute of Medical Virology, Helmut-Ruska-Haus, Campus Mitte, Charite - University Medicine Berlin, Germany; ⁴ Institute of Pathology/Research Center ImmunoSciences (RCIS), Campus Benjamin Franklin, Charite - University Medicine Berlin, Germany



Abstract

HIV entry into CD4⁺ cells requires interaction with a cellular receptor, generally either CCR5 or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral replication remained absent despite discontinuation of antiretroviral therapy after transplantation with CCR532/32 stem cells. However, it was expected that the long-lived viral reservoir would lead to HIV rebound and disease progression during the process of immune reconstitution. In the present study, we demonstrate successful reconstitution of CD4⁺ T cells at the systemic level as well as in the gut mucosal immune system following CCR532/32 stem cell transplantation, while the patient remains without any sign of HIV infection. This was observed although recovered CD4⁺ T cells contain a high proportion of activated memory CD4⁺ T cells, i.e. the preferential targets of HIV, and are susceptible to productive infection with CXCR4-tropic HIV. Furthermore, during the process of immune reconstitution, we found evidence for the replacement of long-lived host tissue cells with donor-derived cells indicating that the size of the viral reservoir has been reduced over time. In conclusion, our results strongly suggest that cure of HIV has been achieved in this patient.


**** me, we're going to live forever.

[gruntmods]

They cured one instance. Its going to be a very long time before we develop an actual cure.

[Slidell]

They cured one instance. Its going to be a very long time before we develop an actual cure.

Once we figure something out we improve and make new versions of exponentially faster. There's a study out there that shows it. You don't even have to look at the study. It took us thousands and thousands of years to figure out how to fly. Once we did we were on the moon in 57 years.


Oh by the way, thanks for ******** on my point.

[gruntmods]

Once we figure something out we improve and make new versions of exponentially faster. There's a study out there that shows it. You don't even have to look at the study. It took us thousands and thousands of years to figure out how to fly. Once we did we were on the moon in 57 years.


Oh by the way, thanks for ******** on my point.

It will still be years before we make a cure.

[Slidell]

It will still be years before we make a cure.

But we're making one.

[gruntmods]

But we're making one.

unless the scientists get aids.

[Slidell]

unless the scientists get aids.

Then they'll have more reason to cure it.

[blacklabelfosho]

In conclusion, our results strongly suggest that cure of HIV has been achieved IN THIS PATIENT.

[Slidell]

******* you guys are pessimistic and pedantic.

[Quinn]

Condoms are good too.

[connorss]

Condoms are good too.

1: ^this is win
2: it's not condoms,it's CONDAAMN'S

[gruntmods]

In conclusion, our results strongly suggest that cure of HIV has been achieved IN THIS PATIENT.

YAY! now we just cure it millions of more times! Easy right?

[Slidell]

YAY! now we just cure it millions of more times! Easy right?

I'm going to ram a machete up your asshole, asshole.

[Lockon]

Hmm...Just recently they announced a cure to cancer....I am Legend anyone?

[gruntmods]

Hmm...Just recently they announced a cure to cancer....I am Legend anyone?

they announced a cure for cancer?
This topic is about aids bro.

[Randomrocket]

Hmm...Just recently they announced a cure to cancer....I am Legend anyone?

if only they could cure retardedness...... some people are just a lost cause I guess

[gruntmods]

if only they could cure retardedness...... some people are just a lost cause I guess

I assume thats why they invented the blast furnace.

[Lockon]

Im sure that the cure for HIV will only work for some people

[gruntmods]

Im sure that the cure for HIV will only work for some people

or monkeys

[Slidell]

or monkeys

It's all that one guy that ****** a chimps fault. ******* it. Furries caused AIDS.